Gut Immunology


The Gut Immunology is a gastrointestinal stool test that evaluates immunological imbalance specific to gastrointestinal tract inflammatory disease activity. Gastrointestinal inflammation is reported through the biomarkers Calprotectin and Eosinophil Protein X. Calprotectin is highly sensitive for evaluating inflammation within the gastrointestinal tract. The United States Food and Drug Administration (FDA) cleared calprotectin as a marker intended for differentiating Irritable Bowel Syndrome (IBS) from Inflammatory Bowel Disease (IBD). Calprotectin is a useful clinical tool for identifying patients who warrant further GI evaluation. Eosinophil Protein X reflects IgE–mediated inflammation. Fecal EPX elevations can be associated with several conditions including IBD, IgE–mediated food allergies, parasite or worm infections and collagenous colitis. Test Type: Stool Test Please contact us for pricing




Parasitology


This gastrointestinal test evaluates stool for the presence of intestinal parasites, using microscopic examination. This gastrointestinal test is an ideal stool analysis for patients with sudden changes in bowel pattern, especially those who have been traveling abroad or camping. Symptoms of intestinal parasites can include:

  • Diarrhea
  • Cramps
  • Nausea
  • Fever
  • Vomiting
  • Abdominal Pain
  • Fatigue
Test Type: Stool Test Please contact us for pricing




H. Pylori Stool Antigen HpSA


Helicobacter pylori is a bacterial infection strongly associated with persistent stomach inflammation. Such inflammation can significantly increase the risk of stomach or duodenal ulcer formation. The stool test is a convenient, non-invasive way of testing for H.pylori for both diagnosis and follow-up testing. This marker can also be added to other larger stool tests by request. Please contact us for pricing




IBStatus


IBStatus™ offers a concise look at the overall health of the gastrointestinal (GI) tract. It is a non-invasive evaluation that uses biotechnology to evaluate digestion, inflammation, and gut flora. With IBStatus™, you can quickly identify causes of chronic GI complaints while delivering timely targeted clinical management including whether or not a patient should have a more invasive procedure like a colonoscopy. IBStatus™can help identify the cause and guide treatment. Please contact us for pricing




Secretory Immunoglobulin A


SIgA is an important indicator of digestive immune function. Chronic intestinal infections (due to bacterial, yeast or parasites), food sensitivities, aging, antibiotics, medication and stress all decrease sIgA levels. Low levels can lead to recurrent infections and food intolerances. Very low levels of this important antibody class have also been observed in autistic spectrum disorders. Please contact us for pricing




Coeliac Profile - (Gluten Sensitivity)


Zonulin is a protein modulator of intestinal tight junctions that is used to assess intestinal permeability (IP). Recent peer-reviewed literature highlights the role that intestinal permeability plays in a host of chronic GI and systemic conditions. Patients who may benefit from Zonulin assessment include those with: Leaky Gut Symptoms – bloating, gas, cramps, food sensitivities, joint pains, skin rashes and autoimmunity

  • Coeliac Disease
  • GI Disorders – gluten sensitivity, IBS
  • Cardiometabolic Diseases – type 1 diabetes, type 2 diabetes, obesity, non-alcoholic fatty liver disease, and insulin resistance
The Coeliac & Gluten Sensitivity test tests a patient's blood for total IgA as well as IgA specific antibodies for possible coeliac disease or gluten sensitivity. Coeliac disease, also known as coeliac sprue or gluten sensitivity enteropathy, is a chronic autoimmune disease which has a genetic component and may affect several family members. Coeliac is a lifelong condition with no cure however, it is manageable once diagnosed. What is Coeliac Disease? Coeliac disease is a digestive condition triggered by consumption of the protein gluten, which is found in bread, pasta, cookies, pizza crust, and many other foods containing wheat, barley, or rye. When a person with Coeliac Disease eats food containing gluten, an immune reaction occurs in the small intestine, resulting in damage to the surface of the small intestine and an inability to absorb certain nutrients from food. Conditions, diseases, and symptoms related to Coeliac Disease:
  • Abdominal cramps, gas, and bloating
  • Anaemia
  • Crohn's Disease
  • Diarrhea
  • Foul-smelling or grayish stools that may be fatty or oily
  • Gastric ulcers
  • General weakness
  • Intermittent diarrhea
  • Irritable Bowel Syndrome (IBS)
  • Osteoporosis
  • Parasitic infections
  • Skin disorders
  • Stunted growth (in children)
  • Weight loss
  • Lupus erythematosus
  • Type 1 diabetes
  • Rheumatoid arthritis
  • Autoimmune thyroid disease
  • Microscopic colitis
Test Type: Blood Test Please contact us for pricing




Comprehensive Parasitology Profile


The Comprehensive Parasitology is a gastrointestinal stool test which evaluates for presence of parasites. Additionally the stool test evaluates levels of beneficial flora, imbalanced flora, pathogenic bacteria, and yeast. This stool test can help reveal hidden causes behind acute or chronic conditions that develop from parasitic infection or dysbiosis. The Comprehensive Parasitology stool test is ideal for patients with sudden changes in bowel pattern, especially for those who have been traveling abroad or camping. Susceptibility to Parasite Infection: It is generally assumed that travel to a Third World country or the occasional camping trips are prerequisites for acquiring a parasite infection. The truth is the combination of extensive worldwide travel, increasing immigration to the United States, day care centers (and other sources of easy transmission) -- anyone is now susceptible. Diarrheal diseases, in fact, (bacterial as well as parasitic) constitute the greatest worldwide cause of morbidity and mortality. Parasite Pathogenicity: Various organisms are increasingly recognized for their potential pathogenicity. For example: Giardia lamblia is the leading cause of intestinal parasitic infection in the United States. Only a few decades ago it was not considered pathogenic. Cryptosporidium, a well-known pathogen in animals, was only recently identified as a human pathogen. Blastocytis hominis is the most frequently observed fecal parasite. Its level of pathogenicity continues to be controversial. Pathogenicity, in general, appears to vary depending on the parasite itself, host susceptibility, and the microbiological environment in which the parasite lives. Parasitic Symptoms of Infection: The most common symptoms of parasite infection are diarrhea and abdominal pain. Other parasitic symptoms may include flatulence, anorexia, weight loss, fevers, chills, blood or mucus in the stool, and fatigue. Parasitic Systemic Complaints: We generally think of parasite infections as causing acute gastrointestinal symptoms. An increasing number of parasite cases feature systemic complaints not traditionally associated with parasites, such as:

  • Urticaria
  • Reactive arthritis
  • Chronic fatigue syndrome
  • Asthma
  • Constipation in individuals who are immune-compromised or whose intestinal flora is chronically imbalanced
Diagnosing Parasitic Infections: The diagnosis of parasitic infections depends on the laboratory, with detection rates dramatically increasing with more sophisticated procedures. Genova Diagnostics' Comprehensive Parasitology test profile uses the most technologically advanced procedures to accurately identify a wide range of protozoal parasites, including amoebae, flagellates, ciliates, coccidian, and microsporidia. Specimens are carefully analyzed by highly-trained technicians using computer-enhanced microscopy, new staining procedures, and advanced immunoassay techniques. These accurate detection methods allow for increased detection rates, intensifying the awareness of the important relationship between parasitic infection and a broad spectrum of illnesses. Test Type: Stool Test Please contact us for pricing




Microscopic Examination for Worms


Examination for adult cestodes, nematodes and trematodes or macroscopic worms or pieces of worms that may be shed in the stool.​​​​​​​




Comprehensive Digestive Stool Analysis (Parasitology Optional)


The Comprehensive Digestive Stool Analysis (CDSA) offers a comprehensive look at the overall health of the gastrointestinal (GI) tract. The CDSA is a historic evaluation of gastrointestinal function assessing a select set of stool biomarkers. This stool analysis evaluates: ​​​​​​​

  • This stool analysis evaluates:
  • Digestion/Absorption Markers
  • Immunology (Inflammation) Markers
  • Pancreatic Elastase 1 (PE1), a biomarker of exocrine pancreatic function Immunology (Inflammation) Markers
  • Calprotectin, an FDA-cleared biomarker that effectively differentiates between Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD)
  • Gut Metabolic Markers
  • Gut Microbiology Markers
  • Gold standard O&P (ova & parasite) technology as well as EIA (Enzyme Immunoassay) for identification of common parasites
This diagnostic stool analysis provides immediate, actionable clinical information for the estimated 50% of patients seen by primary care practitioners who have gastrointestinal complaints. For greater insight into the clinical utility of the CDSA please read the Clinical Overview below. CDSA Stool Analysis Offers Insight into Common Gastrointestinal Conditions Evidence suggests that both local and systemic health issues may begin as imbalances in gastrointestinal function. Some of the consequences of imbalanced gastrointestinal health are:
  • Maldigestion
  • Malabsorption
  • Irritable Bowel Syndrome (IBS)
  • Altered GI immune function
  • Bacterial/fungal overgrowth
  • Chronic dysbiosis
What is the Comprehensive Digestive Stool Analysis (CDSA)? The Comprehensive Digestive Stool Analysis (CDSA) provides unique insight into overall and gastrointestinal health by assessing a combination of novel stool biomarkers. The CDSA provides an informative and flexible screening of gastrointestinal function providing information on:
  • Digestion/Absorption:
  • Pancreatic Elastase 1
  • Putrefactive Short–Chain Fatty Acids
  • Additional biomarkers available
  • Chymotrypsin
  • Fecal Fats
  • Inflammation/Immunology:
  • Eosinophil Protein X (EPX)
  • Calprotectin
  • Gut Metabolic Markers
  • Beneficial Short–Chain Fatty Acids (SCFA) with n–Butyrate
  • pH
  • Beta–Glucuronidase
  • Secondary Bile Acids
  • Lithocholic acid (LCA)
  • Deoxycholic acid (DCA)
  • LCA/DCA Ratio
  • Gut Microbiology Markers
  • Beneficial Bacteria
  • Additional Bacteria
  • Mycology
  • Parasitology Microscopic
  • Parasitology EIA
  • Cryptosporidium
  • Giardia lamblia
  • Entamoeba histolyti
When Should the CDSA 2.0 be considered? CDSA can reveal important clinical information about many common symptoms such as gas, bloating, abdominal pain, diarrhea, and constipation. This stool analysis also provides assessment for a differential diagnosis between inflammatory bowel disease and irritable bowel syndrome, plus a reliable assessment of exocrine pancreatic function. In addition, patients with risk factors for parasite acquisition can be evaluated with the CDSA 2.0. What advantage does the CDSA 2.0 offer compared to other diagnostics? Traditional GI testing has required advanced imaging and inconvenient testing procedures that can be costly. The CDSA 2.0 stool analysis offers a user-friendly way to provide clinicians with valuable insight into GI imbalances What can clinicians and patients expect from the CDSA offer compared to other diagnostics? Evidence suggests that both local and systemic health issues may begin as imbalances in Gastrointestinal function. The CDSA 2.0 stool test provides immediate, actionable clinical information for patients presenting with GI complaints. It aids clinicians in the identification of root cause(s) of digestive discomfort and supports identification of targeted treatments. Test Type: Stool Analysis Please contact us for pricing




Leaky Gut


We are is excited to announce the offering of stool and serum Zonulin as an Add-On to several of our highly utilised gastrointestinal and immunology diagnostic profiles: Zonulin is a protein modulator of intestinal tight junctions that is used to assess intestinal permeability (IP). Recent peer-reviewed literature highlights the role that intestinal permeability plays in a host of chronic GI and systemic conditions. Patients who may benefit from Zonulin assessment include those with: Leaky Gut Symptoms – bloating, gas, cramps, food sensitivities, joint pains, skin rashes and autoimmunity Coeliac Disease GI Disorders – gluten sensitivity, IBS Cardiometabolic Diseases – type 1 diabetes, type 2 diabetes, obesity, non-alcoholic fatty liver disease, and insulin resistance Please contact us for pricing




Small Intestinal Bacterial Overgrowth - Lactulose


Breath testing measures the hydrogen and methane gases produced by bacteria in the small intestine that has diffused into the blood, then lungs, for expiration. These gases are produced by bacteria, yeast or archaea, not by humans, and are tracked on a graph over the small intestine transit time of 2-3 hours. A sugar solution of glucose or lactulose is taken after a 1 or 2 day preparatory diet, which removes much of the food that would feed the bacteria, allowing for a clear reaction to the sugar drink. There are two types of breath test: lactulose and glucose. Please ensure you choose the correct challenge agent when ordering:

Lactulose Breath Test


Lactulose is a non-digestible sugar to humans: only bacteria can metabolise it, and they then produce gas. If there is an overgrowth, this will be reflected in the levels of hydrogen or methane gases. Lactulose takes longer to metabolise than glucose and can therefore help assess the distal end of the small intestine.

The test is performed at home. There should be a 24 hour preparation period prior to starting the test, which should be started with a 12 hour preparation diet followed by a 12 hour overnight fast , this process will take 3 hours to collect the samples at timed intervals.

  • IBS
  • Fibromyalgia
  • Chronic Fatigue Syndrome
  • Bloating
  • Brain Fog
  • Upper quadrant pain
Please contact us for pricing





Digestion

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© 2018 Lifestyle & Innovation, Fitness Therapies

30 Park View Road

Ealing, London, W52JB

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Tel: 07951365567

info@LIFTclinic.co.uk

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