Metabolic Analysis Profile


The Metabolic Analysis Profile is a nutritional test that assesses urine metabolites in order to evaluate four critical areas of metabolism: gastrointestinal function, cellular and mitochondrial energy production, neurotransmitter processing, and amino acid/organic acid balance as influenced by vitamin/mineral cofactors. Results can be used to address chronic systemic complaints ranging from chronic fatigue and mood disorders to headache, muscular/joint pain, and digestive problems. The Metabolic Analysis Profile is a nutritional test using an urinary assessment of 46 key organic acids grouped according to their primary roles in the following four central areas of metabolism.
Gastrointestinal Function — This profile measures eight markers that can reveal malabsorption and dysbiosis. These imbalances can be addressed to improve gut health and to help prevent or alleviate: chronic digestive problems, common causes of nutritional deficiency, yeast overgrowth, cognitive impairment, gastrointestinal distress, and degenerative conditions. Energy Production —This profile assesses metabolites that serve as important intermediates in the citric acid (Krebs) cycle. This cycle supplies the body with its primary energy needs, converting 90% of food energy into cellular energy. This subpanel also includes:

  • Carbohydrate metabolites that can signal impaired glucose metabolism
  • Markers that help evaluate the breakdown of fats and production of cholesterol
  • A marker measuring the production of coenzyme Q10
Imbalances of cellular energy metabolites are linked with chronic fatigue, accelerated cell breakdown, and unhealthy aging. Neurotransmitter Metabolites - A special grouping of neurotransmitter metabolites serve as important diagnostic indicators of abnormal metabolism that can underline many key aspects of neuropsychiatric function. These markers are urinary metabolites of powerful neurotranmitters that act on the central nervous system, including: Epinephrine, Dopamine, and Serotonin. These substances can profoundly influence patterns of stress response, emotional well-being, cognition, and sleep. Assessment of Nutrient Sufficiency — This nutritional test provides a functional assessment of nutrient sufficiency and usage that covers a broad range of vitamins, coenzymes, elements, enzyme activators, and other nutrients. An analysis of amino acid metabolites which require vitamin and mineral cofactors for their metabolism can hint at deficiencies of: vitamins B6, B12 and C, magnesium, copper, iron, and various amino acids. The reference ranges for this test apply to children (2 — 12 years) and adults. Test Type: Urine Test Please contact us for pricing




Organic Acids Testing


The Organic Acid Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. Additionally, children's reference ranges are designed to provide more accurate pediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. Organic Acids and Nutritional Testing Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth. The Organic Acid Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:

  • Functional vitamin and mineral status
  • Amino acid insufficiencies like carnitine and NAC
  • Oxidative damage and antioxidant need
  • Phase I & Phase II detoxification capacity
  • Functional B-complex vitamin need
  • Neurotransmitter metabolites
  • Mitochondrial energy production
  • Methylation sufficiency
  • Lipoic acid and CoQ10 status
  • Markers for bacterial and yeast overgrowth
Organic Acid Testing and Clinical Solutions: Full review of the patient's biochemical status and metabolic pathway flow can help identify areas of greatest concern. Follow-up nutritional testing can monitor the effectiveness of selected treatments. Advantages of the Organic Acid Comprehensive Profile
  • Extensive Analyte List - The Organic Acid Comprehensive Profile is a nutritional test which contains one of the most extensive biomarker lists in the industry. Including nutritional markers such as Quinolinate, D-Arabinitol, and 8-Hydroxy-2'deoxyguanosine.
  • Innovative Method - The LC/MS-MS method, which is also used to screen newborns for metabolic disorders, requires very little sample preparation and processing. This technology provides more stability, accuracy, and sensitivity in measuring organic acids at low levels for optimum test results.
  • Single Urine Specimen - A single overnight urine collection is easy for patients, leading to increased patient compliance.
The Organic Acid Comprehensive nutritional test is ideal for patients who may suffer from:
  • Weight issues
  • Sleep abnormalities
  • Depression
  • Chemical Sensitivities
Test name(s): 0091 - Organix® Comprehensive Profile We also offer less comprehensive versions of this test as well as some of the individual components. Please contact us for pricing




Metabolic Syndrome Profile


Insulin resistance/insensitivity is closely linked with obesity, and occurs when the body stops being responsive to insulin. This leads to higher and higher levels of insulin being secreted by the pancreas in an attempt to maintain normal blood sugar levels. This profile measures other factors associated with 'Metabolic Syndrome' including hsCRP, insulin, cholesterol, triglycerides and glycosylated haemoglobin - a marker of long-term elevated blood glucose levels.





Energy Metabolism

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