Adrenal - Thyroid Profile


Adrenal evaluation is commonly considered for patients with fatigue and a host of other complaints resulting from a history of chronic psychological or physiological stress. However adrenal evaluation is also vital for treating patients with hypothyroidism, due to the close interaction of these endocrinal systems. Urinary T3 levels are a sensitive measure of the active thryoid hormone which can give an accurate reflection of overall thyroid hormone levels. To help evaluate these intricately-linked areas, we have developed the Adrenal-Thyroid Profile. This consists of the Adrenal Stress Profile, (salivary cortisol and DHEA), as well as urinary T3 levels. Please contact us for pricing




Chronic Fatigue Screen


This test combines the Adrenal Stress Profile and Metabolic Analysis tests to provide a comprehensive analysis of various factors that may be implicated in chronic fatigue and other related conditions. Test Type: Urine Test, Saliva Test Please contact us for pricing




Comprehensive Adrenal Stress Profile


The Comprehensive Adrenal Stress Profile comprises of the standard Adrenal Stress Profile (which assesses cortisol and DHEA levels) and Secretory IgA (SIgA). Imbalances of cortisol, DHEA and SIgA can lead to the most common health complaints of the 21st century. Both excesses and deficiencies of DHEA and cortisol have been implicated in the aetiology of various illnesses and immune suppression. Please contact us for pricing




DHEA Level


This single saliva sample measures DHEA levels, a stress hormone that decreases with age and can affect all areas of health and wellbeing. It also allows for monitoring of DHEA supplementation, which should be carefully monitored. Please contact us for pricing




Homocysteine


Total plasma homocysteine levels are widely implicated in a variety of clinical conditions and are an independent risk factor for cardiovascular, atherothrombotic and cerebrovascular disease. Certain key nutrients, including Vitamin B12, Vitamin B6 and folic acid, are necessary for homocysteine metabolism; therefore this test can also provide valuable information about a patient's nutritional status relating to these nutrients. Please contact us for pricing




Essential Oestrogens FMV/24Hr


Essential Oestrogens is a targeted urinary hormone test designed to evaluate oestrogen metabolism specifically. This hormone test offers clinical insight into parent oestrogens, key oestrogen metabolites, and relevant ratios and is useful for initial oestrogen assessment as well as follow-up testing to monitor response to therapies and/or to check levels of previously abnormal results. Essential Oestrogens with Genomics Personalise Patient Treatment Protocols with Genomic Testing We are excited to announce that the addition of select genomic markers to our Essential Oestrogens profile. Assessment of these select genomic markers (also known as SNPs) in conjunction with urine hormone testing, supports broadened clinical insight into women's and men's health concerns. Genomic testing using these SNPs may provide awareness into an array of conditions for which the peri/menopausal and andropausal patient seek support such as anxiety and other mood shifts, cardiovascular disease, cardiometabolic syndrome, bone health and hormone detoxification capacity. Complete Hormones kit requisitions will now include the option for ordering one or more of the following SNPs: MTHFR – Methylenetetrahydrofolate Reductase

  • Low bone mineral density and/or fracture risk
  • Potential risk of all cancers
  • Low levels of B vitamins, especially folate
  • Risk for cardiovascular disease and stroke
COMT – Catechol-O-Methyltransferase
  • Mood Disorders
  • Chronic, high levels of stress
  • Increased risk for fracture
  • High or imbalanced estrogen levels, especially 4-hydroxyestrogn
VDR – Vitamin D Receptor
  • Autoimmune diseases
  • Metabolic syndrome
  • Cancer risk and progression
  • Osteopenia/osteoporosis
CY1B1 – Cytochrome P450 1B1
  • Increased risk for cancers in specific populations
  • Exposure-specific cancers
Oestrogen imbalance can produce challenging symptoms during the transitional periods of perimenopause/ menopause and andropause (male menopause) including:
  • Weight gain
  • Anxiety
  • Fatigue
  • Low sex drive and performance issues
  • Hair loss
  • Sleep disturbances
  • Mood instability
  • Brain fog
  • Hot flashes
Why use the Essential Oestrogens profile? In conventional hormone testing, basic parent hormones (oestrogens, progesterone, etc.) are usually measured in blood. However, urinary hormone testing, as offered in Essential Oestrogens, provides several advantages: Urinary hormone testing provides a more comprehensive look at hormone metabolism, measuring basic parent hormones, as well as compounds produced from parent hormones Emerging research reinforces the potential relationship of disease risk with downstream oestrogen metabolites, which are not routinely measured in blood testing and not available in salivary testing. Available as a convenient at-home collection of a first-morning or 24-hour specimen The Essential Oestrogen test is a subpanel of Complete Hormones, a more comprehensive evaluation of sex- and steroid-hormone biomarkers. Test Type: Urine Test Please contact us for pricing




Estrogen Profile w/(optional) Bone Resorption Profile


The Estronex Profile with Bone Resorption measures six important estrogen metabolites, as well as current bone loss. Assessment includes: The "Good" Estrogen 2-hydroxyestrone (2-OHE1) - high levels of 2-OHE1 are ideal to reduce cancer growth. 2-hydroxyestradiol (2-OHE2) - shown to exhibit anti-carcinogenic effects. 2-methoxyestrone (2-OMeE1) - OMeE1 has shown to have anticancer effects and is ideal in high levels. 4-methoxyestrone (4-OMeE1) - as a non-cancerous metabolite, OMeE1 generally does not require treatment at high levels in the body. The "Bad" Estrogen 4-hydroxyestrone (4-OHE1) - considered a "bad" estrogen, 4-OHE1 levels should be low, as high levels may react negatively with damaged DNA. 16-α-hydroxyestrone (16α-OHE1) - also considered a "bad" estrogen, 16α-OHE1 in high levels may encourage tumor development. The Ratios 2-OHE:16α-OHE1 (2:16 ratio) - 2:16 ratios less than 2.0 indicate increasing long-term risk for breast, cervical, and other estrogen sensitive cancers. Importantly, nutritional interventions can help raise Estronex 2:16 ratios and decrease long-term risk. Studies also indicate that this risk is modifiable! 2-OHE1:2-OMeE1 - a high level of 2-OHE1:2-OMeE1 may also indicate imbalanced estrogen metabolism and low activity in the COMT gene. Evaluation of methylation activity is recommended. Collagen Breakdown (follow same treatment as "The Ratios", et al) Deoxypyridinoline - a fragment of Type I collagen breakdown that contains the cross-linking point and has been demonstrated to be more specific to bone resorption than breakdown fragments measured in some earlier assays. Test name(s): 0145 - Estronex Profile with Bone Resorption Method: UPLC Tandem Mass Spectrometry Please contact us for pricing




Female Hormonal Health


This test provides a focused overview of hormonal balance in both pre- and post-menopausal women, using a single serum sample to evaluate dynamics of sex steroid metabolism that can profoundly affect a woman's health throughout her lifetime. Please contact us for pricing




Complete Hormones w/(optional) Genomics


Advancing the Clinical Utility of Urinary Hormone Testing Complete Hormones is our most comprehensive urinary hormone test, designed to assist in the clinical management of hormone-related conditions. This hormone test assesses parent hormones, their metabolites, and key metabolic pathways, providing information about the impact that shifting hormone levels can have in men (andropause or male menopause) and women (perimenopause/menopause), producing symptoms such as:

  • Weight gain
  • Anxiety
  • Fatigue
  • Low sex drive and performance issues
  • Sleep disturbances
  • Mood instability
  • Brain fog
  • Hot flashes
Complete Hormones with Genomics Personalize Patient Treatment Protocols with Genomic Testing We are excited to announce that the addition of select genomic markers to our Complete Hormones profile. Assessment of these select genomic markers (also known as SNPs) in conjunction with urine hormone testing, supports broadened clinical insight into women's and men's health concerns. Genomic testing using these SNPs may provide awareness into an array of conditions for which the peri/menopausal and andropausal patient seek support such as anxiety and other mood shifts, cardiovascular disease, cardiometabolic syndrome, bone health and hormone detoxification capacity. Complete Hormones kit requisitions will now include the option for ordering one or more of the following SNPs: MTHFR – Methylenetetrahydrofolate Reductase
  • Low bone mineral density and/or fracture risk
  • Potential risk of all cancers
  • Low levels of B vitamins, especially folate
  • Risk for cardiovascular disease and stroke
COMT – Catechol-O-Methyltransferase
  • Mood Disorders
  • Chronic, high levels of stress
  • Increased risk for fracture
  • High or imbalanced estrogen levels, especially 4-hydroxyestrogn
VDR – Vitamin D Receptor
  • Autoimmune diseases
  • Metabolic syndrome
  • Cancer risk and progression
  • Osteopenia/osteoporosis
CY1B1 – Cytochrome P450 1B1
  • Increased risk for cancers in specific populations
  • Exposure-specific cancers
Why use the Complete Hormones profile? In conventional hormone testing, basic parent hormones are usually measured in blood. However, urinary hormone testing with Complete Hormones provides several advantages:
  • Urinary hormone testing provides a more comprehensive look at hormone metabolism
  • Emerging research reinforces the potential relationship of disease risk with downstream metabolites, especially those of the 4-hydroxylation estrogen pathway, which are not routinely measured in blood or salivary testing
  • Evaluation of stress-hormone metabolic pathways provides an indicator of balance between anabolic and catabolic metabolism
  • Offers convenient, at-home collection of a first-morning or 24-hour specimen
Imbalanced hormone production affects a wide range of body functions, producing symptoms that negatively affect the quality of life and may increase the risk for hormone-related diseases. Identification and targeted treatment of hormonal imbalances using customized hormone and/or nutritional therapies improves symptoms,quality of life, and may reduce disease risk. While the Complete Hormones profile is the most comprehensive profile, Genova also offers smaller sub-panels that assess a more select set of urine-hormone biomarkers, allowing for targeted initial assessment as well as follow-up testing to monitor therapy response and/or to check levels of previously abnormal results. For more information on these sub-panels, please click on these links:
  • Essential Estrogens – a focused evaluation of estrogen metabolism, including parent hormones, metabolites, and key ratios
  • Estrogen Metabolism Assessment – a focused measurement of specific hydroxyestrogens, providing a rapid, convenient way of assessing the balance between two estrogen biomarkers (2/16 ratio)

Clinical Overview What is the Complete Hormones test? Complete Hormones is our most comprehensive urinary hormone profile, and is designed to assist with the clinical management of hormone-related symptoms in both male and females. This profile assesses parent hormones and their metabolites as well as key metabolic pathways, provides insight into the contribution that sex hormones may have in patients presenting with hormone-related complaints, and helps assess disease risk associated with elevated estrogen metabolites. Urine measures the most metabolites, providing more insight into associated disease risk. The Complete Hormones profile evaluates:
  • Progesterone (via pregnanediol)
  • Glucocorticoids, including cortisol
  • Androgens, including DHEA and testosterone, and their metabolites
  • Estrogens (E1 Estrone, E2 Estradiol, E3 Estriol) and metabolites, including hydroxylated and methoxylated estrogens
  • Methylation capacity
  • 5α-reductase activity
  • Anabolic/Catabolic Balance
The unique report configuration provides for easy interpretation and clinically actionable results:
  • The Steroidogenic Pathway-At-A-Glance page allows the clinician to see patient results along the metabolic cascade, allowing a quick assessment of potential areas of concern in hormone production and metabolism.
  • The Interpretation-At-A-Glance page summarizes results through color-coded graphic representations of overall hormonal balance and metabolism, highlighting key ratios for easier test interpretation and clinical application.
When should the Complete Hormones test be considered? The Complete Hormones test is designed to assist in the management of hormone-related symptoms in both males and females. The Complete Hormones test is ideal for establishing a baseline assessment of parent hormones and their metabolites ahead of clinical intervention with hormone therapy (HT) as well as subsequent monitoring if needed in both female and male patients. The Complete Hormones test provides insight into the impact that shifting hormone levels may play in men (andropause or male menopause) and women (peri/menopause). Symptoms include the following:
  • Weight gain
  • Anxiety
  • Fatigue
  • Muscle mass loss
  • Muscle weakness
  • Low libido and sexual performance issues
  • Hair loss
  • Sleep disturbances
  • Brain fog
  • Mood instability
  • Hot flashes
  • Vaginal dryness
In addition to supporting patient management around hormone-dependent symptoms, the profile provides valuable insight into disease risk for hormone-associated cancers (breast, prostate) and osteoporosis. What advantage does Complete Hormones profile offer compared to other hormone tests? The conventional clinical approach to hormone-related symptoms (such as those experienced by patients in the perimenopause/menopause transition) does not routinely include utilization of comprehensive urine hormone testing. When testing is performed, basic parent-hormone blood testing is generally the test of choice, since serum testing is well represented in the literature. However, urinary assays provide several advantages over blood assays for patients with hormone-related symptoms.
  • Steroid hormones naturally fluctuate over the course of a day and measurement of hormones in urine collected over several hours provides a stable average of hormone levels that overcomes the “snapshot” limitation inherent in serum testing.
  • Emerging research reinforces the potential relationship of disease risk with individual hormone metabolites, particularly downstream estrogen metabolites – especially those of the 4-hydroxylation pathway. Given the close interrelationships of steroid hormones, a comprehensive assessment comprising these metabolites is recommended, at least for an initial evaluation. Complete Hormones provides measurement of these metabolites with a convenient patient-friendly collection for people with normal renal function who are not on diuretic medications.
  • In addition to the measurement of multiple steroid hormones and enzymatic pathways, this profile also measures indicators for the effects of stress on an individual. The Anabolic/Catabolic Balance refers to the balance between “growth and healing” (anabolic) and “wear and tear” (catabolic) in the body. Both anabolic and catabolic metabolism are essential to health. For example, a healthy body requires sufficient time and androgens to rebuild/repair cells (anabolic), but also sufficient corticosteroids to respond to stressors and to discharge cellular debris/toxins (catabolic).
  • The Interpretation-At-A-Glance page summarizes results through color-coded graphic representations of overall hormonal balance and metabolism, highlighting key ratios for easier test interpretation and clinical application.
What can clinicians and patients expect from Complete Hormones testing? Imbalanced or insufficient hormone production affects a wide range of body functions, producing symptoms that negatively affect the quality of life. Imbalanced or insufficient hormone production affects a wide range of body functions, producing symptoms that negatively affect the quality of life and, with some metabolic pathways, may increase risk for hormone-related diseases. A structured diagnostic hormone panel — such as Complete Hormones — to evaluate underlying hormonal imbalances provides clinical utility by supporting insight into development of personalized treatments. Identification and targeted treatment of underlying hormonal imbalances with customized HT and/or nutritional interventions improves symptoms and quality of life — and may reduce disease risk. Parent Hormones
  • Personalized HT based on clinical symptomology and urine hormone assessment
A/C Balance
  • Supportive therapeutics for modulating a high or low A/C Balance include stress management, adequate sleep, reducing stimulants such as caffeine, reducing high glycemic load foods, and adrenal nutritional and botanical support.
5α-Reductase Activity
  • Therapeutic strategies for 5α-reductase inhibition include pharmaceutical intervention with 5α-reductase inhibitors (such as Finasteride) or botanical inhibitors (such as saw palmetto).
Unfavorable estrogen metabolite profile
  • In patients with a low 2-hydroxylation result, metabolism may be shifted toward this pathway by dietary interventions rich in cruciferous vegetables; exercise that increases lean body mass and decreases BMI; and supplementation with indole-3-carbinol (I3C) or diindolylmethane (DIM), as well as omega-3 fatty acids, and B vitamins.
Compromised methylation
  • Numerous factors support methylation including SAMe; the amino acid, methionine; magnesium; B vitamins including folate; trimethylglycine (TMG); glutathione; and stress management strategies that reduce catecholamine production.
  • Studies demonstrate that when DNA is incubated with quinones in the presence of an antioxidant, the formation of the DNA adducts is reduced. Support of antioxidant activity appears to be a reasonable proactive step for reducing risk of hormone-related disease. Several natural compounds have exhibited the ability to minimize DNA adduct formation including resveratrol, N-acetylcysteine (NAC), lipoic acid, and melatonin. Cruciferous and allium vegetables also demonstrate the ability to induce glutathione S-transferases.
Please contact us for pricing




Male Hormonal Health


The Male Hormonal Health™ is a hormonal test which provides a focused overview of hormonal balance in men.Using a single serum sample, the Male Hormonal Health™ test evaluates dynamics of sex steroid metabolism that can profoundly affect a man's health throughout his lifetime. The Male Hormonal Health™ profile is a hormonal test that focuses specifically on DHEA, Sex Hormone Binding Globulin (SHBG), Estradiol, Testosterone, Dihydrotestosterone (DHT), Insulin-like Growth Factor 1 (IGF-1), and Prostate Specific Antigen (PSA). Hormones: The Key to Vitality, Sex Drive, and Aging Hormones play a powerful role in the body's regulatory system. Proper hormonal balance isessential to maintain optimal health and play a crucial role in how onefeels. Testosterone, for example, enhances sex drive, strengthens bone and muscle tissue, and reduces fatproduction. In addition, it is a natural energy booster that protects against the onset of depression and heartdisease. Other male hormonal deficiencies or excesses affect sleep, metabolism, and the ability to fight disease. Throughout life, and particularly in onesmiddle age, information about the body's hormone production provides keen insights to help maintain a health and vigorous life. Test Type: Blood Test Please contact us for pricing




Melatonin Profile (Sleep)


Melatonin is a hormone that controls the daily circadian rhythm and is best known for its role in helping to initiate sleep. Imbalances can also include depression, Seasonal Affective Disorder (SAD), behavioural changes, mood disorders, and stress among others. Please contact us for pricing




Menopause Analysis


Menopause Plus is a comprehensive, non-invasive salivary/urine assay for the analysis of oestradiol, progesterone, testosterone and oestrogen metabolites as well as cortisol, DHEA, and melatonin. Results can be used to identify imbalances contributing to menopause symptoms and various systemic disorders, and to determine the need for hormone replacement therapy as well as the effect of stress hormones on sex hormones. Please contact us for pricing




Metabolic Syndrome Profile (Insulin)


Insulin resistance/insensitivity is closely linked with obesity, and occurs when the body stops being responsive to insulin. This leads to higher and higher levels of insulin being secreted by the pancreas in an attempt to maintain normal blood sugar levels. This profile measures other factors associated with 'Metabolic Syndrome' including hsCRP, insulin, cholesterol, triglycerides and glycosylated haemoglobin - a marker of long-term elevated blood glucose levels. Please contact us for pricing




Neopterin/Biopterin Profile (Neurotransmitters)


Products of Tetrahydrobiopterin (BH4) Neopterin and biopterin are by-products of the redox reactions involving tetrahydrobiopterin (BH4). BH4 functions as a cofactor for the enzymes responsible for the production of monoamine neurotransmitters (ephinepherine, norepinephrine, DOPA, serotonin), and as a cofactor in nitric oxide production. Neopterin is a marker of inflammation and cellular immune response, allowing detection and monitoring of inflammatory processes. Neopterin is elevated in:

  • Infections
  • Autoimmune diseases: Rheumatoid Arthritis, Systemic Lupus, and Atopic Asthma
  • Conditions of T-cell or macrophages activation
  • Psychiatric disorders
  • Sleep-disordered breathing
  • Neurological Disease
  • Neopterin/Biopterin Profile
A simple overnight urine specimen; no blood draw is necessary! Test name(s): 0088 - Neopterin/Biopterin Profile* Method: LC/MS-MS, Spectrophotometry Test Type: Urine Test Please contact us for pricing




One Day Progesterone/Oestradiol


This test includes the measurement of oestradiol and progesterone from a single saliva sample. It is recommended for post-menopausal women, those taking hormone supplementation, or as an economical means of assessing luteal-phase hormone levels in pre-menopausal women. Test Type: Saliva Test Please contact us for pricing




Female Biorhythm Hormone Test


Female biorhythm hormone test is a comprehensive assessment of estradiol, progesterone, and testosterone spanning a full 28 days. Additionally, this hormone testing profile includes the Adrenocortex Stress Profile and the Comprehensive Melatonin Profile to reveal how the sex hormones are influenced by cortisol, DHEA, and melatonin. Hormone imbalances revealed in this hormone test can help illuminate root causes of disorders such as premenstrual syndrome (PMS), infertility, and menstrual irregularities. Hormonal balance is the key. Research has long shown that fluctuating levels of estradiol, progesterone, and testosterone play a major role in a woman´s overall health. Hormone imbalances can affect:

  • Menstrual cycle
  • Mood swings
  • Sleep patterns
  • Appetite level
  • Sex drive
Chronic hormonal imbalances are implicated in disorders such as:
  • PMS
  • Anovulation
  • Infertility
  • Amenorrhea
  • Endometriosis
  • Polycystic Ovary Disease
  • Osteoporosis
Saliva hormone testing provides a thorough analysis of estradiol and progesterone over a full 28 day cycle. Testosterone is measured once from the 28th day specimen. By utilizing 11 saliva samples for analysis, the relationship and balance of these essential hormones are analyzed more precisely through time. The levels of estradiol and progesterone, as well as the ratio between the two, are clearly graphed for easy reference and patient education. Unlike serum measurements that typically reflect both bound and unbound fractions of hormones, salivary samples represent only the free (unbound) bioavailable fraction of hormone. Factors that affect binding globulin such as obesity and thyroid function do not influence test results with false high or low test levels. Female biorhythm is a hormonal test indicated for both premenopausal and perimenopauseal women not currently supplementing with hormones. An analysis of estrogen, progesterone and testosterone can reveal ovulatory function and trends in hormone production. Hormonal imbalances such as unopposed estrogen, high follicular progesterone, anovulation and luteal phase defects are easily identified. This hormone test is especially useful in treatment of patients with chronic gynecologic disorders. Additionally, the test includes a circadian analysis of cortisol, melatonin, and an assay of DHEA. Test Type: Saliva Test Please contact us for pricing




Testosterone


This test measures salivary testosterone levels, the principal androgen in men, and can allow for the detection of hormonal imbalances related to symptoms of male andropause, as well as those related to imbalanced testosterone commonly found in women. This test can be used to assess baseline levels and monitor testosterone replacement therapy. Test Type: Saliva Test Please contact us for pricing




Total Thyroid Screen w/(optional) Iodine


This test analyses serum levels of TSH, total T4, free T4, free T3, anti-TG antibodies, and anti-TPO antibodies to assess central and peripheral thyroid function, as well as thyroid auto-immunity. Test Type: Serum Test Please contact us for pricing




Bone Resorption: Osteoporosis Risk Assessment


The Bone Resorption Assessment is a simple urinary test that provides an accurate assessment of the rate of bone turnover in an individual. The Bone Resorption Assessment allows the practitioner to identify those more likely to develop osteoporosis, to intervene before significant loss has occurred, and to monitor the efficacy of treatment regimens. It examines pyridinium crosslinks and deoxypyridinoline and is useful in identifying current rate of bone loss, lytic bone disease, and efficacy of bone support therapies. Hormone Testing and Osteoporosis:

  • Osteoporosis leads to 1.5 million fractures per year
  • Osteoporosis affects more than 50% of healthy American women aged 30-40 who are likely to develop vertebral fractures as they age
  • Hormone testing is an important component to identify individuals currently losing bone at an accelerated rate so that effective treatment can begin before significant bone loss has occurred
Measuring Bone Resorption Pyridinium crosslinks are stabilizers of collagen molecules. Bone collagen contains bothpyridinoline (PYD), which is reflective of collagen loss of all types, and its component deoxypyridinoline (DPD), which specifically reflects bone collagen. Presence in the urine of higher than normal amounts of PYD and DPD indicate a rapid rate of bone loss. Crosslink excretion is greatly increased in patients with osteoporosis, as well as in a number of other conditions. These include Paget's disease, primaryhyperparathyroidism, and osteomalacia. Measurement of PYD crosslinks has also proven useful in arthritic diseases, connective tissue disorders, cancer metastasis, and alcoholic bone disease. Test Type: Urine Test Please contact us for pricing




Functional Blood Chemistry Profile


This biochemistry analysis is a full haematology and biochemical assessment for Glucose & lipid metabolism, Renal Function, Adrenal Function, Liver Function, Thyroid & Parathyroid Function and Iron & Inflammation status. Please contact us for pricing





Hormones

Contact

© 2018 Lifestyle & Innovation, Fitness Therapies

30 Park View Road

Ealing, London, W52JB

​​

Tel: 07951365567

info@LIFTclinic.co.uk

Name *

Email *

Subject

Message